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Development of synthesis designs and analytical methods for metal binding and dioxygen activating urea containing ligands

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Title: Development of synthesis designs and analytical methods for metal binding and dioxygen activating urea containing ligands
Author: Yoneyama, Sachiko
Advisor: Scarrow, Robert C.
Department: Haverford College. Department of Chemistry
Type: Thesis (B.S.)
Issue Date: 2006
Abstract: I have explored synthesis methods for three ligand designs. Attempted syntheses of N-tert-Butyl-N'-[2-(2-diethylamino-ethylamino)-ethyl]-urea (H3La), and N- [2-(2-Diethylamino-ethylamino)-ethyl]-N'-(1-ethyl-propyl)-urea (H3Lb) were unsuccessful. Complications caused by primary and secondary amine reactivity yielded an inseparable mixture of products. Although all ligands were designed to be capable of forming a metal complex, and subsequently bind to dioxygen, metal binding experiments indicated H3Lb cannot form metal complexes. One successful synthesis produced a novel ligand, N-salicylidene-(N'-tert-butyl-ureal-2-ethyl)-amine. Several analytical methods (GC/MS, LC/MS, and NMR) were developed to determine effective conditions for analyzing urea containing ligands.
Subject: Ligands -- Synthesis
Subject: Ligand binding (Biochemistry)
Subject: Urea -- Synthesis
Terms of Use: http://creativecommons.org/licenses/by-nc/3.0/us/
Permanent URL: http://hdl.handle.net/10066/9288

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Citation

Yoneyama, Sachiko. "Development of synthesis designs and analytical methods for metal binding and dioxygen activating urea containing ligands". 2006. Available electronically from http://hdl.handle.net/10066/9288.

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http://creativecommons.org/licenses/by-nc/3.0/us/ Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/3.0/us/

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