| dc.contributor.advisor |
Sternberg, Wendy |
en_US |
| dc.contributor.author |
Magid, Jessica R. |
en_US |
| dc.date.accessioned |
2007-02-28T20:31:43Z |
|
| dc.date.available |
2007-02-28T20:31:43Z |
|
| dc.date.issued |
2006 |
en_US |
| dc.identifier.uri |
http://hdl.handle.net/10066/749 |
|
| dc.description.abstract |
In this study, the effects of an early-life painful or stressful experience, specifically a surgery or sham surgery, on adulthood pain, stress, and learning behavior were assessed. The surgery was conducted on two samples of male and female CD-1 mice on the day of birth with or without anxiolytic treatment. These groups were then compared, at two different developmental stages, to unhandled CD-1 subjects. Adulthood pain behavior was assessed using the Hot Plate (HP) and Tail Withdrawal (TW) tests, and baseline and stressor-challenged anxiety were tested using the Elevated Plus-Maze (EPM). We also employed the Morris Water-Maze (MWM) to measure learning behavior. Our results indicate that early-life stress (surgery and sham surgery) appears to increase anxiety behavior and neural activation of stress-related areas following a stressor in adulthood. Additionally, age appears to be a factor in overall adulthood pain and stress behavior, and anxiolytic treatment attenuates the effects of an early-life stressor on pain, stress, and learning behavior, although some of these findings only hold for one sex. |
en_US |
| dc.description.provenance |
Made available in DSpace on 2007-02-28T20:31:43Z (GMT). No. of bitstreams: 2
2006MagidJ.pdf: 232416 bytes, checksum: 4b2b9047e442cba272991705aae6a088 (MD5)
2006MagidJ.pdf.txt: 121930 bytes, checksum: 554c45e827ce3046a09e742be9f5a133 (MD5)
Previous issue date: 2006-05 |
en |
| dc.description.sponsorship |
Haverford College. Dept. of Psychology |
en_US |
| dc.format.extent |
232416 bytes |
en_US |
| dc.format.extent |
121930 bytes |
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| dc.format.mimetype |
application/pdf |
en_US |
| dc.format.mimetype |
text/plain |
|
| dc.language.iso |
en_US |
en_US |
| dc.rights.uri |
http://creativecommons.org/licenses/by-nc/3.0/us/ |
|
| dc.subject.lcsh |
Pain in infants |
|
| dc.subject.lcsh |
Pain -- Physiological aspects |
|
| dc.subject.lcsh |
Stress (Psychology) -- Physiological aspects |
|
| dc.subject.lcsh |
Learning -- Physiological aspects |
|
| dc.title |
Does Early-Life Pain in Mice Affect Adulthood Pain Sensitivity, Stress Behavior, and Learning Behavior? |
en_US |
| dc.type |
Thesis (B.A.) |
en_US |