Does Early-Life Pain in Mice Affect Adulthood Pain Sensitivity, Stress Behavior, and Learning Behavior?

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dc.contributor.advisor Sternberg, Wendy en_US Magid, Jessica R. en_US 2007-02-28T20:31:43Z 2007-02-28T20:31:43Z 2006 en_US
dc.description.abstract In this study, the effects of an early-life painful or stressful experience, specifically a surgery or sham surgery, on adulthood pain, stress, and learning behavior were assessed. The surgery was conducted on two samples of male and female CD-1 mice on the day of birth with or without anxiolytic treatment. These groups were then compared, at two different developmental stages, to unhandled CD-1 subjects. Adulthood pain behavior was assessed using the Hot Plate (HP) and Tail Withdrawal (TW) tests, and baseline and stressor-challenged anxiety were tested using the Elevated Plus-Maze (EPM). We also employed the Morris Water-Maze (MWM) to measure learning behavior. Our results indicate that early-life stress (surgery and sham surgery) appears to increase anxiety behavior and neural activation of stress-related areas following a stressor in adulthood. Additionally, age appears to be a factor in overall adulthood pain and stress behavior, and anxiolytic treatment attenuates the effects of an early-life stressor on pain, stress, and learning behavior, although some of these findings only hold for one sex. en_US
dc.description.sponsorship Haverford College. Dept. of Psychology en_US
dc.format.extent 232416 bytes en_US
dc.format.extent 121930 bytes
dc.format.mimetype application/pdf en_US
dc.format.mimetype text/plain
dc.language.iso en_US en_US
dc.subject.lcsh Pain in infants
dc.subject.lcsh Pain -- Physiological aspects
dc.subject.lcsh Stress (Psychology) -- Physiological aspects
dc.subject.lcsh Learning -- Physiological aspects
dc.title Does Early-Life Pain in Mice Affect Adulthood Pain Sensitivity, Stress Behavior, and Learning Behavior? en_US
dc.type Thesis (B.A.) en_US

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