Does Early-Life Pain in Mice Affect Adulthood Pain Sensitivity, Stress Behavior, and Learning Behavior?
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Title:
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Does Early-Life Pain in Mice Affect Adulthood Pain Sensitivity, Stress Behavior, and Learning Behavior? |
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Author:
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Magid, Jessica R.
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Advisor:
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Sternberg, Wendy
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Department:
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Haverford College. Dept. of Psychology |
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Type:
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Thesis (B.A.) |
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Running Time:
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232416 bytes121930 bytes |
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Issue Date:
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2006 |
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Abstract:
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In this study, the effects of an early-life painful or stressful experience, specifically a surgery or sham surgery, on adulthood pain, stress, and learning behavior were assessed. The surgery was conducted on two samples of male and female CD-1 mice on the day of birth with or without anxiolytic treatment. These groups were then compared, at two different developmental stages, to unhandled CD-1 subjects. Adulthood pain behavior was assessed using the Hot Plate (HP) and Tail Withdrawal (TW) tests, and baseline and stressor-challenged anxiety were tested using the Elevated Plus-Maze (EPM). We also employed the Morris Water-Maze (MWM) to measure learning behavior. Our results indicate that early-life stress (surgery and sham surgery) appears to increase anxiety behavior and neural activation of stress-related areas following a stressor in adulthood. Additionally, age appears to be a factor in overall adulthood pain and stress behavior, and anxiolytic treatment attenuates the effects of an early-life stressor on pain, stress, and learning behavior, although some of these findings only hold for one sex. |
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Subject:
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Pain in infants
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Subject:
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Pain -- Physiological aspects
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Subject:
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Stress (Psychology) -- Physiological aspects
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Subject:
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Learning -- Physiological aspects
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Terms of Use:
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http://creativecommons.org/licenses/by-nc/3.0/us/
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Permanent URL:
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http://hdl.handle.net/10066/749
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Files in this item
Citation
Magid, Jessica R..
"Does Early-Life Pain in Mice Affect Adulthood Pain Sensitivity, Stress Behavior, and Learning Behavior?".
2006. Available electronically from
http://hdl.handle.net/10066/749.
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