Does Early-Life Pain in Mice Affect Adulthood Pain Sensitivity, Stress Behavior, and Learning Behavior?

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Does Early-Life Pain in Mice Affect Adulthood Pain Sensitivity, Stress Behavior, and Learning Behavior?

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Title: Does Early-Life Pain in Mice Affect Adulthood Pain Sensitivity, Stress Behavior, and Learning Behavior?
Author: Magid, Jessica R.
Advisor: Sternberg, Wendy
Department: Haverford College. Dept. of Psychology
Type: Thesis (B.A.)
Running Time: 232416 bytes121930 bytes
Issue Date: 2006
Abstract: In this study, the effects of an early-life painful or stressful experience, specifically a surgery or sham surgery, on adulthood pain, stress, and learning behavior were assessed. The surgery was conducted on two samples of male and female CD-1 mice on the day of birth with or without anxiolytic treatment. These groups were then compared, at two different developmental stages, to unhandled CD-1 subjects. Adulthood pain behavior was assessed using the Hot Plate (HP) and Tail Withdrawal (TW) tests, and baseline and stressor-challenged anxiety were tested using the Elevated Plus-Maze (EPM). We also employed the Morris Water-Maze (MWM) to measure learning behavior. Our results indicate that early-life stress (surgery and sham surgery) appears to increase anxiety behavior and neural activation of stress-related areas following a stressor in adulthood. Additionally, age appears to be a factor in overall adulthood pain and stress behavior, and anxiolytic treatment attenuates the effects of an early-life stressor on pain, stress, and learning behavior, although some of these findings only hold for one sex.
Subject: Pain in infants
Subject: Pain -- Physiological aspects
Subject: Stress (Psychology) -- Physiological aspects
Subject: Learning -- Physiological aspects
Terms of Use: http://creativecommons.org/licenses/by-nc/3.0/us/
Permanent URL: http://hdl.handle.net/10066/749

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Magid, Jessica R.. "Does Early-Life Pain in Mice Affect Adulthood Pain Sensitivity, Stress Behavior, and Learning Behavior?". 2006. Available electronically from http://hdl.handle.net/10066/749.

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http://creativecommons.org/licenses/by-nc/3.0/us/ Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/3.0/us/