Is the lateral septum's inhibitory influence on the amygdala mediated by GABA-ergic neurons?

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2004
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Haverford College. Department of Psychology
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Thesis
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eng
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Open Access
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Abstract
Previous studies suggest that the lateral septum and amygdala are critical in the production and regulation of anxiety. The lateral septum may express its anxiolytic properties by directly inhibiting the activity of the amygdala. The present study examines whether this connection is primarily mediated by GABA-ergic neurons. Rats were fully sedated and an acute recording electrode was placed in the central nucleus of the amygdala; the lateral septum was stimulated during recording. Picrotoxin was injected intraperitoneally and recording was repeated. The interaction effect of picrotoxin and stimulation support the conclusion that GABA does play a central role in this connection.
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