Determining the Cause of Increased Neurogenesis in Dominant Rodents: Dissociating the Effects of Social Hierarchies and Testosterone

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2010
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Haverford College. Department of Psychology
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Thesis
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Award
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eng
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Open Access
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Abstract
Dominant male rodents exhibit higher neurogenesis rates than subordinate rodents. Elevated testosterone levels lead to similar increases in neurogenesis. The current study investigated the relative contribution of testosterone versus social factors to dominance-related neurogenesis. Castrated mice were administered a high dose of testosterone (HT), a low dose (LT), or an oil vehicle (OIL). Mice were then housed individually or in groups to establish dominance hierarchies. Levels of aggression, testosterone, corticosterone and neurogenesis were assessed. While HT mice exhibited the highest testosterone levels, LT mice the most aggression, and OIL mice the most corticosterone, no neurogenesis differences were found.
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