The Sleep-Wake Circadian Rhythm and Depressed Mood in Normal Humans
Date
1992
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Haverford College. Department of Psychology
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Thesis
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Award
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eng
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Haverford users only
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Abstract
The study of circadian rhythms has become very important over the past twenty years in the study of affective disorder. The clinical depression literature has shown REM sleep irregularities in particular to be an indicator of depression, and manipulation and inhibition of REM sleep, behaviorally or through the use of antidepressant drugs has been found to be key in the treatment of depressed patients. It has also been shown that there are similarities between the REM sleep of depressed patients and the REM sleep of normals who undergo extended sleep. This study examines the sleepĀ wake patterns of normals and their corresponding mood variations. It was hypothesized that sleep patterns in normals simulating common depressive sleep symptomatology would be correlated with depressed mood within subjects. While there was some suggestion of a relationship between sleep disturbance and depressed mood, there was not sufficiently significant results to consider this relationship a robust one. Possible improvements of method and future experiments are discussed.