Sex Differences in NMDA-Receptor Involvement in Non-Opioid Analgesia within the Periaqueductal gray of the Rat
Date
1998
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Haverford College. Department of Psychology
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Thesis
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Award
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eng
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Haverford users only
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Abstract
The effects of NMDA, saline and morphine microinjection into the dorsal periaqueductal gray of 10 male and 6 female rat brains was examined. The duration of the analgesia was monitored by performing nociceptive tests, specifically the tail flick and the hot plate tests, directly after injection, and then 15, 30, 45, and 60 minutes after. It was found that males displayed higher mean latencies than females on nociceptive tests following microinjection of NMDA as well as following morphine microinjection. In fact, females displayed a hyperalgesic response to morphine; their morphine latencies were shorter than their saline latencies.