Sex Differences in Non-Opioid Swim Stress-Induced Analgesia in Mice: An Exploratory Study

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1998
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Haverford College. Department of Psychology
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eng
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Haverford users only
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Sex differences in the abilities of glutamatergic, serotonergic, and muscarinic antagonists in attenuating non-opioid stress-induced analgesia (SIA) in mice were examined. SIA was induced by 3 minutes of forced swim in 15°C water and calculated from the response latency on a 53ºC hot plate relative to the response latency obtained prior to swim. Dizocilpine maleate (MK-801), cis-4-(Phosphonomethyl)-2-piperidinecarboxyl acid (CGS 19577), 8-hydroxy-2( di-n-propylamino)tetralin (8-0H-DPAT), and dicyclomine (DCM) were delivered i.p. 20 minutes prior to swim. Previous findings that prepubescent mice of both sexes show MK-801-sensitive analgesia were not replicated. Surprisingly, MK-801 attenuated SIA in females but not in males, a reversal of previously established findings. Low doses of 8-0H-DPAT (0.25 mg/kg) and CGS19577 (1 mg/kg) decreased pre-swim hot plate latencies while a high dose of DCM (50 mg/kg) potentiated pre-swim hot plate latencies, suggesting that these drugs influenced basal nociception. Finally, it is suggested that diurnal variations in the severity of cold swim as a stressor may account for the failure of MK-801 to attenuate SIA in males.
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