Sex Differences in Nonopioid Analgesia: Comparison of Three Potential Analgesia Systems in Female Mice
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1998
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Haverford College. Department of Psychology
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Thesis
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Award
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eng
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Haverford users only
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Abstract
The present research investigated three potential analgesia systems in mice in an attempt to find the underlying neurochemical substrate of a female-specific system of non-opioid analgesia. The systems tested for potential analgesia included the glutamatergic, serotonergic and muscarinic cholineric systems, all of which have been implicated in connection with non-opioid analgesia. After injection of the system-specific analgesia receptor blocker (MK-801, 8-0H-DPAT, CGS 19755 or Dicyclomine) and initial baseline latency measurements, subjects were subjected to a 15°C cold swim stressor and then measured again for subsequent analgesia. Analyses of variance were used to determine level of analgesia and whether the receptor blocker inhibited the analgesia at all in male and female mice. Although no conclusive effects were found, it was clear that present theories for the mechanisms underlying non-opioid analgesia must be examined more closely given the significance of factors such as light-cycle effects and downregulation of receptors.